EP399/#1156 Prevalence and factors associated with malnutrition in the diagnosis of older Brazilian out patients with gynecological cancer: prospective cohort study

Abstract

Objectives To determine the prevalence of malnutrition and predictive factors for the occurrenceof early adverse events (infection, hospitalization and death) IN THE DIAGNOSIS OF OLDER BRAZILIAN OUT PATIENTS WITH GYNECOLOGICAL CANCEr

Methods Prospective cohort enrolled older patients >60 years with a recent gynecological cancer diagnosis admitted between 2015–2019. The CGA performed at the time of admission included the following instruments: CCI; KPS; MMSE; TUG test; IPAQ; ADL; MNA; MNA-SF; GDS15; PPS; Polypharmacy. The outcomes included malnutrition and early death.Survival analysis (Kaplan-Meier) and Cox proportional hazard regression was performed.was performed by univariate analysis by adjusting simple Poisson regression models, considering p<0.20. Then, the variables that found an association were included in a new multivariate Poisson regression model adopting a 5% significance level and 95%

Results In total, 826 patients were included in the study. prevalence of malnutrition in 42,3% of the sample and 14,9% were at risk of malnutrition. During the six months of surveillance, 28.4% of the patients developed a Infrction, 34.6% were hospitalized and 16.4% died. for early death MNA < 23.5(HR= 2.89; 95% CI 1.81–5.99, p<0.001)

Conclusions The prevalence of malnutrition and nutritional risk was high in older women with gycological cancer; and metastatic disease; patients with fall history, sedentary and risk of depression. malnutrition is apredictive factors for the occurrenceof early adverse events (infection, hospitalization and death).It is important evaluate early nutritional status of the group patients, to contribute positively to the clinical outcome of these patients.